What is the relationship between Vitamin E and Mixed tocopherols

November 25, 2024

The relationship between vitamin E and mixed tocopherols can be understood from the following aspects:

1. Definition and Classification:

-Vitamin E is a general term for tocopherols, including four types of tocopherols (alpha, beta, gamma, delta) and four types of tocotrienols.

-These tocopherols and tocotrienols are distinguished based on their side chain structure and the position of the methyl group.

2. Activity and absorption :

-Alpha tocopherol is the most abundant and physiologically active form of vitamin E.

-Natural alpha tocopherol (2RRR_ - α - tocopherol) and synthetic alpha tocopherol (all_rac_ - α - tocopherol) are two forms used in pharmaceutical products and food additives.

-Natural alpha tocopherol (2RRR_ - α - tocopherol) has higher nutritional value and safety than synthetic alpha tocopherol (all_rac_ - α - tocopherol), as only 2R or higher levels of alpha tocopherol can be utilized and absorbed by the body.

3. Antioxidant effect :

-Vitamin E has antioxidant properties, which can prevent and reduce the damage of cell membrane lipid peroxides in the body, maintain tissue integrity, and have functions such as cancer prevention and anti-aging.

-Alpha tocopherol is the main manifestation of vitamin E's antioxidant activity in the body.

4. Metabolism and Function:

-In addition to alpha tocopherol, other forms of vitamin E, such as gamma tocopherol (gamma T), delta tocopherol, and gamma tocotrienol, also have unique antioxidant and anti-inflammatory properties, which may be superior to alpha tocopherol in the prevention and treatment of chronic diseases.

-These non alpha tocopherol forms of vitamin E can be significantly metabolized into carboxychromols through side chain ω - oxidation induced by cytochrome P450, among which long-chain carboxyphenols, especially 13 '- carboxyphenols, have stronger anti-inflammatory effects.

In summary, the relationship between vitamin E and mixed tocopherols is that vitamin E is a general term for various tocopherols and tocotrienols, with alpha tocopherol being the most predominant form, while other tocopherols and tocotrienols also have important physiological functions and antioxidant properties.

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